Garg 4,5-indolyne precursor is an indolyne precursor developed by Professor Neil Garg and coworkers. It is widely used for the synthesis of various N-heterocyclic based compounds. It is also useful for the preparation of substituted indoles (Diels-Alder and azide cycloaddition products).
Synonyms: 4-(Trimethylsilyl)-1H-indol-5-yl trifluoromethanesulfonate
Molecular Formula: C12H14F3NO3SSi
Molecular Weight: 337.39
Linear Structural Formula: C12H14F3NO3SSi
MDL Number: MFCD25976536
Purity: 95%
Melting Point: 43-48 C
Storage: 2-8C
Application: Indolyne precursor can be activated under mild fluoride conditions, which are highly reactive with dienes and other dipolariphiles (e.g. azides) to provide cycloaddition products containing an indole motif.
Other Notes: Regioselective reactions of 3; 4-pyridynes enabled by the aryne distortion model