Synonyms: KQIEIKKFK trifluoroacetate salt; L-lLysyl-L-glutaminyl-L-isoleucyl-L-alpha-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl--L-lysine; Lys-Gln-Ile-Glu-Ile-Lys-Lys-Phe-Ly trifluoroacetate salt
Molecular Formula: C55H96N14O13 · xC2HF3O2
Linear Structural Formula: C55H96N14O13 · xC2HF3O2
Purity: >=95% (HPLC)
Storage: -20C
Application: Gap19 trifluoroacetate salt has been used to inhibit Ca2+/calmodulin (CaM) gating response of connexin 43 (Cx43) gap junctions.
Biochem Physiol Actions: Gap19, nonapeptide from the cytoplasmic loop of Connexin-43, is a selective blocker of connexin 43 (Cx43) hemichannel that does not block GJ or Cx40/Panx-1 channels in cardiomyocytes and astrocytes. Gap19 prevents Cx43 hemichannel opening and protect against myocardial ischemia/reperfusion injury.