GANT61

Synonym: 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl-benzenamine, NSC 136476

CAS Number: 500579-04-4

Empirical Formula (Hill Notation): C₂₇H₃₅N₅

Molecular Weight: 429.60

Biochem/physiol Actions:
GANT61 blocks hedgehog pathway signaling by inhibiting the transcripional activity of Gli1 (IC50 = 5 µM). GANT 61 led to a regression of 22Rv1 human prostate tumor cell xenografts in nude mice.