?-Butyrolactone (GBL) is a related lactone analog of ?-hydroxybutyric acid (GHB), a widespread drug of abuse, identified as an endogenous constituent of the mammalian brain, in which it exhibits a strong central nervous system depressant effect. GBL is considered as a legal substitute of GHB, and commonly identified in beverages including coffee, apple cider vinegar, tea, carbonated drinks, etc.
Synonyms: gamma-Hydroxybutyric acid lactone; 4-Hydroxybutyric acid lactone; GBL
Molecular Formula: C4H6O2
Molecular Weight: 86.09
Linear Structural Formula: C4H6O2
MDL Number: MFCD00005386
Purity: >=99.0% (GC)
Melting Point: -45 C (lit.)
Density: 1.12 g/mL at 25 C (lit.)
Refractive Index: n20/D 1.436 (lit.)
Storage: 2-8C
Application: ?-Butyrolactone may be used as an analytical reference standard for the quantification of the analyte in roasted Italian chestnuts, wine samples, beverages using chromatography techniques.
Biochem Physiol Actions: Precursor of gamma-hydroxybutyric acid (GHB). It blocks dopamine release by blocking impulse flow in dopaminergic neurons. Pretreatment with gamma-butyrolactone allows detection of autoreceptor-induced dopamine release.