Synonyms: gamma-[(6-Azidohexyl)-imido]-adenosine-5'-triphosphate sodium salt
Molecular Formula: C16H28N9O12P3 · xNa+
Linear Structural Formula: C16H28N9O12P3 · xNa+
Purity: >=95% (HPLC)
Storage: -20C
Application: Lee, et al., reported a non-radioactive version of in vitro phosphorylation where ?-[(6-Azidohexyl)-imido]-ATP (compound 6) was successfully used instead of ?-32P-modified ATP to phosphorylate GST-tagged recombinant p27kip1 with protein kinase cdk2. The phosphorylated, azide-modified protein substrate can be labeled with alkynes of biotin or fluorescent dyes using Cu(I)-catalyzed click chemistry or DBCO-containing biotin or fluorescent dyes using Cu(I)-free click chemistry.
Legal Information: The purchase of this product for use in applications relating to copper catalyzed azide-alkyne cycloaddition chemistry ("Click Chemistry") includes a limited, nontransferable license to intellectual property owned by The Scripps Research Institute to use this product solely for internal non-commercial research activities and specifically excludes clinical, therapeutic, or diagnostic use in humans or animals and manufacturing purposes. Information regarding a license for commercial use in Click Chemistry may be obtained directly from The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, or by contacting 858-784-8140 or [email protected].