Synonyms: H-Trp-Glu-OH; L-Tryptophyl-L-glutamic acid; WE
Molecular Formula: C16H19N3O5
Molecular Weight: 333.34
Linear Structural Formula: C16H19N3O5
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: G3335 ( L-tryptophyl-L-glutamic acid) is a cell-permeable dipeptide that acts as a selective and reversible PPARgamma antagonist with a Kd value of 8.34 muM for PPARgamma and much lower activity at other PPAR subtypes. G3335 reversibly and competitively blocks activation of PPARgamma by the PPARgamma agonist rosiglitazone, and conversely, in rat astrocyte culture higher levels of rosiglitazone reduced harmful effects induced by G3335. At higher concentration G3335 may act as a PPARalpha agonist, interacting with the PPARalpha ligand binding domain with a KD of 120 muM. G3335 is reported to reduce hepatic lipid accumulation in lipid-loaded hepatocytes by activation of PPARalpha.