Synonyms: 2,3-Dihydro-N-hydroxy-1,1-dimethyl-2-[5-(trifluoromethyl)-2-pyrazinyl]-1H-isoindole-4-carboxamide; FT 895; FT-895; HDTK 070; HDTK-070; HDTK070; N-Hydroxy-1,1-dimethyl-2-(5-(trifluoromethyl)pyrazin-2-yl)isoindoline-4-carboxamide
Molecular Formula: C16H15F3N4O2
Molecular Weight: 352.31
Linear Structural Formula: C16H15F3N4O2
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: FT895 is a potent and highly selective HDAC11 inhibitor (IC50 = 3 nM/HDAC11, 5.6 muM/HDAC8, >10 muM/HDAC1-7, HDAC9 & HDAC10) with a deacetylase active site Zn2+-targeting hydroxamate. FT895 exhibits antiproliferation potency against myeloproliferative neoplasm (MPN) cultures (IC50 = 3.00 muM/JAK2(V617F) Ba/F3, 4.94 muM/HEL92.1.7, 6.49 muM/MPL(W515L) Ba/F3) and reduces stem-like properties of CSCs (42/62/85/100% inhibtion of H1650 Sphere formation at 0.5/1/2/5 muM).