Synonym: 7ß-Acetoxy-8,13-epoxy-1a,6ß,9a-trihydroxylabd-14-en-11-one, Coleonol, Colforsin
CAS Number: 66575-29-9
Empirical Formula (Hill Notation): C22H34O7
Molecular Weight: 410.50
Beilstein Registry Number: 1692716
EC Number: 266-410-9
MDL Number: MFCD00082317
PubChem Substance ID: 24278035
Biochem/physiol Actions
Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration.1 Forskolin effects calcium currents and inhibits MAP kinase.
Biological Source: from Coleus forskohlii
Assay: =98% (HPLC)
Form: powder
Color: off-white
Solubility: DMSO: soluble5 mg/mL (stable at least 6 months at room temperature)
Gene Information: human ... OPRK1, SLC2A10, TNF