Synonyms: Fondaparin sodium; Methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranosyl-(14)-O-beta-D-glucopyranuronosyl-(14)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranosyl-(14)-O-2-O-sulfo-alpha-L-idopyranuronosyl-(14)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranoside 6-(hydrogen sulfate) sodium salt; SR-90107A
Molecular Formula: C31H43N3O49S8 · 10Na
Molecular Weight: 1728.08
Linear Structural Formula: C31H43N3O49S8 · 10Na
Purity: >=95% (HPLC)
Storage: -20C
Application: Fondaparinux sodium has been used to test its neutralizing effect towards enterovirus D68-947 infection. It may be used in ultraviolet photodissociation (UVPD) measurements.
Biochem Physiol Actions: Fondaparinux sodium is an antithrombotic anticoagulant, a Factor Xa inhibitor. Fondaparinux sodium is chemically related to low molecular weight heparins. Its pentasaccharide structure corresponds to the antithrombin III (ATIII) binding site of heparin. Fondaparinux sodium binding at this site potentiates the natural inhibitory effect of ATIII against factor Xa by a factor of approximately 300, which results in inhibition of thrombin generation.