Synonyms: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)propanoic acid; N-alpha-(9-Fluorenylmethyloxycarbonyl)-4-(trifluoromethyldiazirin)-L-phenylalanine; Diazirine amino acid; Fmoc-Tdf-OH; Photo-Phe; Photo-crosslinking amino acid; Photoprobe building block
Molecular Formula: C26H20F3N3O4
Molecular Weight: 495.45
Linear Structural Formula: C26H20F3N3O4
MDL Number: MFCD30187628
Purity: >=95%
Storage: -20C
Application: Fmoc-L-Photo-Phe-OH is a diazirine-containing, Fmoc-protected phenylalanine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (>=360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907340.
Other Notes: Covalent modifier-type aggregation inhibitor of amyloid-beta based on a cyclo-KLVFF motifMode of Action of cGMP-dependent Protein Kinase-specific Inhibitors Probed by Photoaffinity Cross-linking Mass SpectrometryTrifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formationSimple and Versatile Method for Tagging Phenyldiazirine PhotophoresFishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe SynthesisPhoto-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)