Synonyms: (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-4-(3-methyl-3H-diazirin-3-yl)butanoic acid; (S)-2-(Fmoc-amino)-4-(3H-diazirin-3-yl)pentanoic acid; Diazirine amino acid; Photo-Met; Photo-crosslinking amino acid; Photoprobe building block
Molecular Formula: C21H21N3O4
Molecular Weight: 379.41
Linear Structural Formula: C21H21N3O4
Purity: >=95%
Storage: -20C
Application: Fmoc-L-photo-methionine is a diazirine-containing, Fmoc-protected methionine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (>=360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907375.
Other Notes: Developing diazirine-based chemical probes to identify histone modification 'readers' and 'erasers 'Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probeCovalent Capture of Phospho-Dependent Protein Oligomerization by Site-Specific Incorporation of a Diazirine Photo-Cross-LinkerFishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe SynthesisPhoto-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)