Fmoc-Cys(STmp)-OH [1] is a novel new tool for the regioselective synthesis of multiple disulfide bridged peptides. The STmp group is stable to piperidine but is extremely easy to remove by mild thiolysis. Albericio [2] has reported removing four STmp groups on the solid phase with only three 5 minute treatments of 0.1 M N-methylmorpholine (NMM) in DMF containing 5% DTT.
Synonyms: Fmoc-Cys(STmp)-OH; N-alpha-Fmoc-S-2,4,6-trimethoxyphenylthio-L-cysteine
Molecular Formula: C27H27NO7S2
Molecular Weight: 541.64
Linear Structural Formula: C27H27NO7S2
Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany