Chlorotrimethylsilane, puriss., >=99.0% (GC)

Synonyms: TMCS; Trimethylchlorosilane; Trimethylsilyl chloride

CAS Number: 75-77-4

Formula: C3H9ClSi

Formula Weight: 108.64

Linear Formula: (CH3)3SiCl

MDL No.: MFCD00000502

Purity: >=99.0% (GC)

Boiling Point: 57 C(lit.)

Melting Point: -40 C (lit.)

Density: 0.856 g/mL at 25 C(lit.)

Refractive Index: n20/D 1.387(lit.)

Beilstein Registry Number: 1209232

EC Number: 200-900-5

UNSPSC Code: 12352000

General description: Chlorotrimethylsilane is a chloro-organosilane compound mainly used for silylation reactions.

Application: . Chlorotrimethylsilane can be a non-toxic alternative to mercuric chloride as activator in samarium-promoted cyclopropanation of both allylic and α-allenic alcohols.. It can be used in combination with hexamethyldisilazane for the protection of alcohols by forming trimethylsilyl ethers via silylation.. It is employed in chloromethylation of polysulfones (PSUs).. It activates lithium hydride to convert it into a hydride source for the reductive silylation of carbonyl compounds.. Chlorotrimethylsilane/lithium bromide forms an effective reagent for the conversion of alcohols to bromides.. Chlorotrimethylsilane/sodium iodide in acetonitrile is a better alternative to iodotrimethylsilane for the cleavage of esters, lactones, carbamates, and ethers. It can also be used for the conversion of alcohols to iodides.. Chlorotrimethylsilane along with silver or ammonium nitrate forms an efficient regioselective nitrating reagent for the ipso-nitration of arylboronic acids to form the corresponding nitroarenes.. Chlorotrimethylsilane along with sodium nitrite or nitrate can be used for deoximation reactions.

Other Notes: Silylating agent