Synonyms: 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride
Formula: (CH3O)2C6H3CH2CH2N(CH3)(CH2)3C[C6H3(OCH3)2][CH(CH3)2]CN · HCl
Formula Weight: 491.06
CAS No.: 152-11-4
Storage Temperature: room temp
General description: This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34.
Biochem/physiol Actions: α1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.
Other Notes: Values of analytes vary lot to lot.
Grade: certified reference material
MP: 142°C (dec.)(lit.)
Packaging: pkg of 1 g
Pharmacopeia Traceability: traceable to PhEur V0100000
Storage Temp.: room temp