Synonyms: 5,11-Dihydro-indolo[3,2-b]carbazole-6-carboxaldehyde; 6-Formylindolo[3,2-b]carbazole
Molecular Formula: C19H12N2O
Molecular Weight: 284.31
Linear Structural Formula: C19H12N2O
Purity: >=95% (HPLC)
Storage: -20C
Biochem Physiol Actions: FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor that activates the expression of aromatic hydrocarbon metabolizing enzyme genes such as the CYP1A1 gene and has also been shown to have multiple additional roles in cell-cycle regulation, development and maturation of many tissues, control of inflammation, and immune response. FICZ is a photoproduct of tryptophan and is believed to be an endogenous AhR ligand. It is extremely potent, with a Kd value of 0.07 nM.