Fetuin is a protein containing 12 Cys residues, all involved in disulfide bridges. The composition of bovine fetuin (weight %) is polypeptide 74%, hexose 8.3%, hexosamines 5.5%, and sialic acid 8.7%.
Fetuin bovine is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification. Fetuin also contributes to the attachment and spreading of cells in culture medium.
A glycoprotein recovered from the globulin fraction of fresh calf serum by ammonium sulfate fractionation.
Key Applications: Insulin inhibitor
Application Areas: Molecular Biology
Product Type: Proteins, Enzymes & Peptides
Extinction Coefficient (E1%): E1%: 4.1 (278 nm); 4.5 (278 nm) (Lit.)
Presentation: Powder
Format: Powder
Isoelectric point (pI): 3.31; 3.2 - 3.8 (Lit.)
pH: 7.12 (2% water)(Lit.)
Solubility: Soluble in 20 mM sodium phosphate buffer, pH 6.8. Soluble in water (1 mg/mL).
Storage & Handling: Store at +4°C.
Certifications: The raw material for this product was collected from USDA registered establishments. The animals were inspected under a veterinarian and were found free from infectious and contagious diseases.