A synthetic salen-manganese complex with high superoxide dismutase (SOD), catalase, and oxyradical scavenger activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents beta-amyloid peptide (Abeta)-induced free radical formation and lipid peroxidation and imparts protection against Abeta40 and Abeta42 toxicity in hippocampal cultures.
Synonyms: EUK-8 - Calbiochem
Molecular Formula: C16H14ClMnN2O2
Molecular Weight: 356.69
Linear Structural Formula: C16H14ClMnN2O2
Purity: >=90% (elemental analysis)
Biochem Physiol Actions: Reversible: no
Legal Information: Not available for sale in Africa, Australia, Great Britain, Europe, Latvia, New Zealand, and the United States.
Other Notes: Colparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol.130, 359.Brandier, C., et al. 1997. J. Vasc. Res. 34, 49.Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247.Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312.Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331.Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.