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Synonyms: 4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside); VP-16-213
Molecular Formula: C29H32O13
Molecular Weight: 588.56
Linear Structural Formula: C29H32O13
MDL Number: MFCD00869325
Storage: 2-8C
Biochem Physiol Actions: Etoposide is an antitumor agent that complexes with topoisomerase II and DNA to enhance double-strand and single-strand cleavage of DNA and reversibly inhibit religation. Blocks the cell cycle in in S-phase and G2-phase of the cell cycle; induces apoptosis in normal and tumor cell lines; inhibits synthesis of the oncoprotein Mdm2 and induces apoptosis in tumor lines that overexpress Mdm2.
Other Notes: Sales restrictions may apply.