Erlotinib hydrochloride is an antineoplastic drug. It regulates mechanistic target of rapamycin (mTOR) inhibition, epidermal growth factor receptor down-regulation and epidermal interstitial transformation (EMT) suppression.
Synonyms: 774 hydrochloride; CP-358; N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride; OSI-744 hydrochloride
Molecular Formula: C22H23N3O4 · HCl
Molecular Weight: 429.9
Linear Structural Formula: C22H23N3O4 · HCl
MDL Number: MFCD07781272
Purity: >=98% (HPLC)
Storage: -20C
Application: Erlotinib hydrochloride has been used to activate mitochondrial fragmentation in a human PANC-1 pancreatic cancer cell line.
Biochem Physiol Actions: Erlotinib hydrochloride is an inhibitor of the receptor tyrosine kinase EGFR (epidermal growth factor receptor). It is used clinically for the treatment of non-small cell lung cancer (NSCLC) and in combination for metastatic pancreatic cancer.