Synonym: ET-1
CAS Number: 117399-94-7
Empirical Formula (Hill Notation): C109H159N25O32S5
Molecular Weight: 2491.90
MDL Number: MFCD00133305
PubChem Substance ID: 24894656
Amino Acid Sequence
Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp [Disulfide Bridges: 1-15; 3-11]
Other Notes
A synthetic peptide with the sequence of human and porcine Endothelin 1.
The biological source is human endothelin, which shares the same sequence.
Biochem/physiol Actions
Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1a, and, thus, the production of VEGF.
Assay: =97% (HPLC)
Form: powder
Color: white
Solubility: 1% acetic acid: >1 mg/mL; H2O: >1 mg/mL
Storage Temp.: -20°C
Gene Information: human ... EDN1