Synonyms: 1,3-bis[2-Methyl-2-(phenylthioxomethyl)hydrazide]propanedioic acid; GSK842879A; N'1,N'3-Dimethyl-N'1,N'3-di(phenylcarbonothioyl)malonohydrazide; NSC 174939; NSC174939; STA 4783; STA-4783; STA4783
Molecular Formula: C19H20N4O2S2
Molecular Weight: 400.52
Linear Structural Formula: C19H20N4O2S2
MDL Number: MFCD12911784
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: Elesclomol (STA-4783) is a copper (II)-chelating malonohydrazide derivative that exerts its in vitro and in vivo anticancer efficacy via reactive oxygen species (ROS)/oxidative stress & apoptosis induction in a Cu(II)-dependent manner (GI50 = 12 nM without vs. 129 nM with Cu2+ removal by TRIEN in K562 culture; typical conc. range 0.1-2 muM in cultures). Elesclomol chelates extracellular Cu(II) for mitochondria delivery, where upon Cu2+ reduction (to Cu+) & ROS generation, copper-free elesclomol then exits cells for continual Cu(II) shuttling and accumulation in mitochondria. In addition to Cu2+, elesclomol can also chelate Co2+ and Ni2+, but not Fe3+ or Zn2+.