Synonyms: 4-((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethynyl)benzoic acid; 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl]benzoic acid; AGN 190205; AGN-190205; AGN190205; BASF 46928; BASF-46928; BASF46928; EC 23; EC-23
Molecular Formula: C23H24O2
Molecular Weight: 332.44
Linear Structural Formula: C23H24O2
MDL Number: MFCD18086921
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: EC23 is a synthetic, photostable all-trans retinoic acid (ATRA) analog/mimetic that targets RAR with greater affinity than ATRA (RARalpha/beta/gamma EC50 by cell-free TR-FRET binding assay = 3.7/3.3/16.8 with EC23 vs. 16.0/17.6/14.7 nM with ATRA) and does not bind retinoid x receptors (RXRs). EC23 induces differentiation of human pluripotent embryonic stem cells (0.1-10 muM) with a similar or better efficiency than ATRA.