Synonym: Doxycycline hydrochloride hemiethanolate hemihydrate
CAS Number: 24390-14-5
Empirical Formula (Hill Notation): C22H24N2O8 · HCl · 0.5H2O · 0.5C2H6O
Molecular Weight: 512.94
Beilstein Registry Number: 5702728
MDL Number: MFCD07357237
PubChem Substance ID: 24278399
Application
Doxycycline hyclate is a synthetic oxytetracycline derivative. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks1. It is used to inhibit matrix metalloproteinases2 and has been used to inhibit the inflammatory response of Lyme Disease3.
Biochem/physiol Actions
Derivative of oxytetracycline. A broad spectrum inhibitor used to inhibit matrix metallo-proteinases (MMP) such as type 1 collagenase in studies on would healing and tissue remodeling.
Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi3. It is a broad spectrum inhibitor of matrix metalloproteinases in vivo.