Synonyms: (2-Benzyl-4-{[(2-methyl-2-propanyl)oxy]carbonyl}piperazinyl){4-[(4-trifluoromethoxy)phenyl]-1H-1,2,3-triazol-1-yl}methanone; 3-(Phenylmethyl)-4-[[4-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazol-1-yl]carbonyl]-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester
Molecular Formula: C26H28F3N5O4
Molecular Weight: 531.53
Linear Structural Formula: C26H28F3N5O4
MDL Number: MFCD31807614
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: DO34 is a brain-penetrant, selective and highly potent diacylglycerol lipase inhibitor (recom human DAGLalpha/beta pIC50 = 8.2/8.1 by SAG hydrolysis; mouse brain DAGLalpha/beta pIC50 = 9.1-9.3/8.6 by ABPP ReDiMe) with detectable off-target activity toward only ABHD6 & PLA2G7 among all mouse brain serine hydrolases and little affinity toward cannabinoid receptors CB1/2. DO34 blocks depolarization-induced suppression of excitation (DSE IC50 = 0.18 muM) and inhibition (100% DSI blockage at 1 muM) in mouse cerebellar and hippocampal slices ex vivo, and attenuate LPS-induced neuroinflammatory responses by lowering brain 2-AG & PGE2 level in mice in vivo (50 mg/kg, i.p).