DMH2 is a small molecule, which has ability to inhibit BMP type I receptors. The bone morphogenetic proteins (BMP) signal inhibition further decreases expression of Id proteins in lung cells.
Synonyms: 4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline; VU0364849
Molecular Formula: C27H25N5O2
Molecular Weight: 451.52
Linear Structural Formula: C27H25N5O2
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: DMH2 is a potent antagonist of the BMP receptor activin receptor-like kinase 3 (ALK3, BMPR-IA) that enhance liver regeneration. DMH2 potently inhibits BMP signaling and induced the greatest reduction of cell growth and expression of Id family members in H1299 non-small cell lung carcinoma cells.