Synonyms: CK2 Inhibitor II; 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole; 4,5,6,7-Tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine; 4,5,6,7-Tetrabromo-N,N-dimethyl-1H-benzo[d]imidazol-2-amine; CK2 Inhibitor II; 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole; DMAT
Molecular Formula: C9H7Br4N3
Molecular Weight: 476.79
Linear Structural Formula: C9H7Br4N3
MDL Number: MFCD08705322
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: DMAT is an ATP-competitive (Ki = 40 nM) casein kinase 2 (CK2) inhibitor (IC50 = 140 nM; rat liver CK2, [ATP] = 20 nM) with greatly improved potency and selectivity than its structure analog TBB. With the exception of DYRK1a (IC50 = 120 nM), DMAT is reported to exhibit no CK1 inhibitiory potency up to 200 muM (50% inhibition by 29 muM TBB) and little or no activity against a panel of 32 other protein kinases, nor PI3K alpha and gamma. When tested in Jurkat cultures, DMAT is shown to be a superior apoptosis inducer than TBB (DC50 = 2.7 muM/DMAT vs. 17 muM/TBB).