Synonyms: (2E/Z)-3-[(3-Nitrophenyl)amino]-1-phenyl-2-propen-1-one; (E/Z)-3-((3-nitrophenyl)amino)-1-phenylprop-2-en-1-one; (E/Z)-3-(3-Nitrophenylamino)-1-phenylprop-2-en-1-one; (E/Z)-DJ001; Compound 3071; Compound 5483071
Molecular Formula: C15H12N2O3
Molecular Weight: 268.27
Linear Structural Formula: C15H12N2O3
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: DJ001 is a selective, allosteric and non-competitive receptor protein tyrosine phosphatase-sigma (PTPsigma) inhibitor (IC50 = 1.43 muM; >10 muM/20 other phosphatases) that promotes BM hematopoietic stem/progenitor cells (HSPCs) expansion (0.1-1 mug/mL or 0.373-3.73 muM; murine CD34- KSL cells) and suppresses radiation-induced BM HSC apoptosis (1-5 mug/mL; murine KSL & human CD34+ cells) via RhoGTPase/RAC1 activation and BCL-XL induction. DJ001 accelerates hematologic recovery and improves survival of irradiated mice in vivo (5 mg/kg/d s.c.). The (Z)- & (E)-isomers exist in equilibrium in polar solvents with (Z) showing enhanced binding-affinity to PTPsigma catalytic & allosteric sites.