Synonyms: 2,2'-Disulfanediylbis(N-(4-sulfamoylphenyl)benzamide; 2,2'-Dithiobis[N-[4-(aminosulfonyl)phenyl]benzamide]; NSC 654077; PD022551
Molecular Formula: C26H22N4O6S4
Molecular Weight: 614.74
Linear Structural Formula: C26H22N4O6S4
Purity: >=97% (NMR)
Storage: room temp
Biochem Physiol Actions: DIBA-1 (2,2′-dithiobisbenzamide-1) is a disulfide that interacts with zinc fingers as a zinc ejector. It has been shown to interact with many zinc finger containing proteins, including HIV-1 nucleocapsid and the estrogen receptor. DIBA-1 has been studied as a candidate for the treatment of AIDS and also breast cancer. In one study DIBA restored tamoxifen sensitivity in resistant breast cancer.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.