Diallyl trisulfide, a constituent of garlic and onions, is a proapoptotic compound that also posesses antioxidant activity.
Synonyms: Allyl trisulfide; Di-2-propenyl trisulfide
Molecular Formula: C6H10S3
Molecular Weight: 178.34
Linear Structural Formula: C6H10S3
MDL Number: MFCD00040025
Purity: >=98% (HPLC)
Storage: -20C
Application: Diallyl trisulfide has been used to study its anti-carcinogenic properties in glioma and bladder cancer cells.
Biochem Physiol Actions: Diallyl trisulfide inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells. Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2.