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MP Biomedicals

Dextran Sulfate Sodium Salt, Colitis Grade

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Dextran Sulfate Sodium Salt, Colitis Grade

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Key features and details

  • Induces severe colitis (inflamatory bowel disease)
  • Highest sulfur content – 19%
  • Highest chirality - +104° of specific rotation
  • Lowest pH – 6.2 at 1% solution

Dextran sulfate sodium salt, or DSS, is a synthetic sulfated branched polysaccharide derivative of dextran that has multiple uses in biomedical and clinical research (see table below). One important property of DSS is to trigger colitis in mice and rats by binding to medium-chain-length fatty acids in the colon and inducing intestinal inflammation.

Application Notes

Dextran sulfate sodium (DSS) is one of the most common and effective compounds used for inducing ulcerative colitis in animals. The DSS colitis model has also been used extensively to study colon cancer developing in relation to colonic inflammation, such as that occurring in patients with long-standing ulcerative colitis.

MP Biomedicals offers the gold standard of colitis model creation reagents - colitis grade dextran sulfate sodium salt (36,000-50,000) and colonic carcinogen azoxymethane (AOM).

Because of its high efficacy, MP Biomedical DSS is one of the most widely used DSS products in the scientific literature. Over the past 19 years more than 10,000 scientific publications have cited the use of MP Biomedicals’ DSS products and reported successful animal model establishment.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Acute/ Chronic Ulcerative Colitis Model Induction, Chronic Colitis Associated Colon Cancer Model Induction

 

SKU02160110-CF
Alternate NamesDSS, Dextran Sodium Sulfate
Application Notes

Dextran sulfate sodium (DSS) is one of the most common and effective compounds used for inducing ulcerative colitis in animals. The DSS colitis model has also been used extensively to study colon cancer developing in relation to colonic inflammation, such as that occurring in patients with long-standing ulcerative colitis.

MP Biomedicals offers the gold standard of colitis model creation reagents - colitis grade dextran sulfate sodium salt (36,000-50,000) and colonic carcinogen azoxymethane (AOM).

Because of its high efficacy, MP Biomedical DSS is one of the most widely used DSS products in the scientific literature. Over the past 19 years more than 10,000 scientific publications have cited the use of MP Biomedicals’ DSS products and reported successful animal model establishment.

Base Catalog Number160110
Boiling Point310° C
CAS #9011-18-1
GradeColitis Grade
Melting Point92° C
Molecular Weight36,000 - 50,000 Da
Personal Protective EquipmentEyeshields, Gloves, respirator filter
pH(1% aqueous solution) 5-7.11

 

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Thomas No.
C837J21
Mfr. No.
0216011001
Description
Dextran sulfate sodium salt, colitis grade (36,000 - 50,000), 1 g
Thomas Select Item
CAS Number
9011-18-1
Grade
Colitis
Packaging Size
1 g
Packaging Type
Bottle, Plastic
Pkg. Type
list price/quantitytotal
$0.00
Thomas No.
C837J22
Mfr. No.
0216011010
Description
Dextran sulfate sodium salt, colitis grade (36,000 - 50,000), 10 g
Thomas Select Item
CAS Number
9011-18-1
Grade
Colitis
Packaging Size
10 g
Packaging Type
Bottle, Plastic
Pkg. Type
list price/quantitytotal
$0.00
Thomas No.
C837J23
Mfr. No.
0216011025
Description
Dextran sulfate sodium salt, colitis grade (36,000 - 50,000), 25 g
Thomas Select Item
CAS Number
9011-18-1
Grade
Colitis
Packaging Size
25 g
Packaging Type
Bottle, Plastic
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list price/quantitytotal
$0.00
Thomas No.
C837J24
Mfr. No.
0216011050
Description
Dextran sulfate sodium salt, colitis grade (36,000 - 50,000), 50 g
Thomas Select Item
CAS Number
9011-18-1
Grade
Colitis
Packaging Size
50 g
Packaging Type
Bottle, Plastic
Pkg. Type
list price/quantitytotal
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Thomas No.
C837J25
Mfr. No.
0216011080
Description
Dextran sulfate sodium salt, colitis grade (36,000 - 50,000), 100 g
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CAS Number
9011-18-1
Grade
Colitis
Packaging Size
100 g
Packaging Type
Bottle, Plastic
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Thomas No.
C837J26
Mfr. No.
0216011090
Description
Dextran sulfate sodium salt, colitis grade (36,000 - 50,000), 500 g
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CAS Number
9011-18-1
Grade
Colitis
Packaging Size
500 g
Packaging Type
Bottle, Plastic
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Thomas No.
C814M95
Mfr. No.
0216011091
Description
Dextran sulfate sodium salt, colitis grade (36,000 - 50,000), 1 kg
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CAS Number
9011-18-1
Grade
Colitis
Packaging Size
1 kg
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Bottle, Plastic
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