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Synonyms: Deferoxamine mesylate salt; DFOM; Deferoxamine methanesulfonate salt; Desferrioxamine mesylate salt
Molecular Formula: C25H48N6O8 · CH4O3S
Molecular Weight: 656.79
Linear Structural Formula: C25H48N6O8 · CH4O3S
MDL Number: MFCD00058605
Storage: 2-8C
Biochem Physiol Actions: An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1muM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 muM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage.
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