Synonyms: Daunomycin hydrochloride
Formula: C27H29NO10 · HCl
Formula Weight: 563.98
CAS No.: 23541-50-6
Storage Temperature: 2-8°C
Biochem/physiol Actions: Naturally fluorescent anthracycline antibiotic, anticancer drug. Substrate for Pgp, MRP-1 and BCRP. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. Daunorubicin is sequestered into lysosomes according to a pH partitioning type mechanism.1,2 Strong inhibitor of DNA and RNA synthesis.