Synonyms: 3-(4-(2,3-Dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)-1,4-diazepan-1-ylsulfonyl)aniline; CID-44543605; DASA 58; DASA58; ML 203; ML-203; ML203; N,N'-DiArylSulfonAmide 58; NCGC00185916
Molecular Formula: C19H23N3O6S2
Molecular Weight: 453.53
Linear Structural Formula: C19H23N3O6S2
MDL Number: MFCD29472280
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: DASA-58 is a potent and selective activator of cancer-specific pyruvate kinase isoform PKM2 (hPKM2 AC50 = 38 nM, Emax = 82%), but not PKM1, PKR or PKL, that stabilizes PKM2 tetrameric conformation by targeting a site distinct from that of fructose-1,6-bis-phosphate (FBP). DASA-58 exhibits good aqueous solubility (51.2 μg/mL), decreases cellular lactate production and suppresses cell proliferation selectively under hypoxic conditions (30 μM; H1299, 1% O2). When administered in mice, DASA-58 is reported to exhibit anti-thrombotic efficacy in vivo (40 mg/kg via iv).