Synonyms: (1R, 2R)-N-myristoylamino-4'-nitro-phenylpropandiol-1, 3; (1R,2R)-B13; B13; N-[(1R,2R)-2-Hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]tetradecanamide; [R-(R*,R*)]-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-tetradecanamide
Molecular Formula: C23H38N2O5
Molecular Weight: 422.56
Linear Structural Formula: C23H38N2O5
MDL Number: MFCD08062172
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: D-NMAPPD (B13), a myristoyl-CoA analog, is a cell penetrant inhibitor of N-myristoyltransferases that suppressed FRS2alpha (fibroblast growth factor receptor substrate 2) myristoylation. D-NMAPPD inhibits wild-type FGFRs and drug-resistant mutants (FGFRsDRM) oncogenic signaling in cancer cells. D-NMAPPD potently inhibits growth of xenograft tumors in mice. D-NMAPPD is a potent inhibitor of ceramidase that elevates endogenous ceramide levels and suppress growth of cancer cells.