Synonyms: 5-(2-Amino-8-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamide; 5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-3-pyridinesulfonamide; CZC-24832
Molecular Formula: C15H17FN6O2S
Molecular Weight: 364.4
Linear Structural Formula: C15H17FN6O2S
MDL Number: MFCD22417090
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: CZC24832 is a potent and selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kgamma) with Kd app of 19 nM. CZC24832 is said to be the first selective PI3Kgamma inhibitor with efficacy in in vitro and in vivo models of inflammation. CZC24832 strongly inhibited T-cell interleukin 17A (IL-17A) production by inhibiting expression of retinoic acid receptor-related orphan receptor gammat (RORgammat), a transcription factor that drives TH17 differentiation, showing a new role for PI3Kgamma.