Synonym: Antibiotic S 7481F1, Cyclosporine
CAS Number: 59865-13-3
Empirical Formula (Hill Notation): C62H111N11O12
Molecular Weight: 1202.61
Beilstein Registry Number: 3647785
MDL Number: MFCD00274558
PubChem Substance ID: 24278028
Biochem/physiol Actions
A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A-cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1a, lipopolysaccharides and TNFa. Can block cytochrome c release from mitochondria.
Quality Level: PREMIUM
Biological Source: from Tolypocladium inflatum
Assay: =95% (HPLC)
Form: Solid
Color: White
Solubility: Dichloromethane: soluble10 mg/mL; ethanol: Soluble10 mg/mL; DMSO: soluble50 mg/mL; Chloroform: soluble6 mg/mL; H2O: insoluble
Storage Temp.: 2-8°C
Gene Information: Human ... PPP3CA(5530), PPP3CB(5532), PPP3CC(5533), PPP3R1(5534), PPP3R2(5535)