Synonym: CHX
CAS Number: 66-81-9
Empirical Formula (Hill Notation): C15H23NO4
Molecular Weight: 281.35
MDL Number: MFCD00082346
PubChem Substance ID: 24892732
Biochem/physiol Actions
Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.
Specificity
Tested for cell growth arrest, selection of cycloheximide resistant yeast, apoptosis induction, and facilitation of apoptosis induction by FasL.
Quality Level: PREMIUM
Biological Source : microbial
Sterility: 0.2 μm filtered
Concentration: 100 mg/mL in DMSO
Storage Temp.: 2-8°C
Gene Information: human ... FKBP1A(2280), PIN1(5300)