Synonyms: 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide; Actidione; Naramycin A
CAS Number: 66-81-9
Formula: C15H23NO4
Formula Weight: 281.35
Linear Formula: C15H23NO4
MDL No.: MFCD00082346
Purity: >=95% (HPLC)
Melting Point: 110-120 C
Beilstein Registry Number: 88868
EC Number: 200-636-0
UNSPSC Code: 51101500
Application: CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins, super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques , activate cumulus-free equine oocytes, and to have neuroprotective properties.
Biochem/physiol Actions: Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.
Biochem/physiol Actions: Inhibits protein biosynthesis in eukaryotic cells by binding with the 80S ribosome
Other Notes: Conditions for safe storage, including any incompatibilities. Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
RTECS: MA4375000
RIDADR: UN2811 - class 6.1 - PG 2 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany: 3
R Codes: 61-28-38-51/53-68
S Codes: 53-45-61
IOD Codes: T+,N
Symbol: GHS06, GHS08, GHS09
Signal Word: Danger
Hazard Statements: H300-H341-H360D-H411
Precautionary statements: P201-P273-P280-P301 + P310 + P330-P308 + P313-P391