Synonyms: 4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid
Molecular Formula: C19H12F3NO3S2
Molecular Weight: 423.43
Linear Structural Formula: C19H12F3NO3S2
MDL Number: MFCD31714171
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: CY-09 is an NLRP3 inflammasone inhibitor. CY-09 binds directly to the ATP-binding motif of NLRP3 NACHT domain and inhibits its ATPase activity, blocking NLRP3 inflammasome assembly and activation. In mouse models CY-09 showed therapeutic effects in type 2 diabetes and cryopyrin-associated auto-inflammatory syndrome (CAPS), which is caused by gain-of-function mutations of NLRP3.