Synonyms: 2,3,6a,7,8,9-Hexahydro-11H-1,4-dioxino[2,3-g]pyrrolo[2,1-b][1,3]benzoxazin-11-one; 2H,3H,6aH-Pyrrolidino[2",1"-3',2']1,3-oxazino[6',5'-5,4]benzo[e]1,4-dioxan-10-one; BDP 37; BDP-37; CX 614; CX-614; LiD 37
Molecular Formula: C13H13NO4
Molecular Weight: 247.25
Linear Structural Formula: C13H13NO4
MDL Number: MFCD13248581
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: CX614 (BDP-37) is a brain-penetrant class I ampakine (benzoxazine subgroup of benzamide-type) with AMPA receptor (AMPAR; iGluR) positive allosteric modulator (PAM) activity via targeting a binding site shared by cyclothiazide (CTZ), but distinct from that of GYKI 52466. CX614 enhances field excitatory postsynaptic potentials (amplitude & duration) in rat hippocampal slices and autaptically evoked excitatory postsynaptic currents in neuronal cultures (EC50 of 20-40 muM) by blocking desensitization and slowing deactivation of responses to glutamate. CX614 is also widely employed for studying AMPAR-mediated physiological responses in vivo (1-10 mg/kg n rats and mice via i.p.).