Synonym: (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Diferulylmethane, Natural Yellow 3
CAS Number: 458-37-7
Linear Formula: [HOC6H3(OCH3)CH=CHCO]2CH2
Molecular Weight: 368.38
Beilstein Registry Number: 2306965
Color Index Number: 75300
EC Number: 207-280-5
MDL Number: MFCD00008365
PubChem Substance ID: 24892983
Biochem/physiol Actions
A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
Packaging
500 mg in poly bottle
Vapor Density: 13 (vs air)
Assay: ≥80% (Curcumin); ≥94% (curcuminoid content)
Solubility: ethanol: soluble1 mg/mL; DMSO: >11 mg/mL; 0.5 M NaOH: soluble (then immediately diluted in PBS)
Storage Temp.: −20°C
Gene Information: human ... APP(351); CYP1A2(1544)