Synonyms: 4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile; 5-(4-Cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole; 5-(4-Cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole; AN2728
Molecular Formula: C14H10BNO3
Molecular Weight: 251.05
Linear Structural Formula: C14H10BNO3
MDL Number: MFCD17169940
Purity: >=98% (HPLC)
Storage: room temp
Biochem Physiol Actions: Crisaborole is a non-steroidal anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor. Crisaborole has an IC50 value of 490 nM for PDE4 with similar IC50 values for release of cytokines TNF-alpha, IL-2, and IFN-gamma, and shows little inhibition against other PDE isozymes. Crisaborole has been approved as a topical treatment for atopic dermatitis.
Legal Information: Sold for research purposes under agreement from Pfizer Inc.