Synonyms: (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Molecular Formula: C19H18ClN5OS
Molecular Weight: 399.9
Linear Structural Formula: C19H18ClN5OS
MDL Number: MFCD27997886
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: CPI203 is an inhibitor of BRD4, a bromodomain-containing protein that binds to histones to regulate recruitment of transcription factors. BRD4 is also an RNA Pol II kinase. CPI203 blocks BRD4 kinase activity in cells and in vivo. It has shown synergistic antitumor activity with lenalidomide in bortezomib-resistant mantle cell lymphoma.