CAS Number 7081-44-9
Linear Formula C19H17ClN3O5SNa · H2O
Molecular Weight 475.88
EC Number 211-390-9
MDL number MFCD00150735
PubChem Substance ID 24893156
Storage temp. 2-8°C
Application
Cloxacillin is a semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. It is also known as cloxacillin sodium. It is used to treat infections caused by penicillin G-resistant staphylococci. It has been used in studies of topical antibacterial agent for burn and crush wounds.
Biochem/physiol Actions
Cloxacillin inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins (PBPs), which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Cloxacillin may interfere with autolysin inhibitors. Cloxacillin is used as an AmpC β-lactamase inhibitor in combination with β-lactam antibiotics.
Cloxacillin is used as an AmpC β-lactamase inhibitor in combination with β-lactam antibiotics.