A tricyclic antidepressant that potently inhibits serotonin and norepinephrine reuptake (Kis = 7.4 and 96 nM, respectively); also an antagonist at histamine, muscarinic acetylcholine, α1-adrenergic, and dopamine receptors (Kds = 31, 37, 38, and 190 nM for H1, M1, α1, and D2, respectively).