Clobazam is a benzodiazepine, comprising of B ring nitrogen placed in positions 1 and 5 contrary to 1,4-benzodiazepines. It is a ligand for ?-aminobutyric acid type A (GABAA) receptor and is metabolized by cytochrome P450 in the liver.
Synonyms: 7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione
Molecular Formula: C16H13ClN2O2
Molecular Weight: 300.74
Linear Structural Formula: C16H13ClN2O2
MDL Number: MFCD00079069
Application: Clobazam has been used as a benzodiazepine to test its effect on the activation of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR).
Biochem Physiol Actions: Clobazam interacts at a and ?2 subunits junction of the GABAA receptor. It is less sedative and elicits anxiolytic and anticonvulsant effects. Clobazam is more selective on the a2 subunit of the GABAA receptor than the a1 subunit. It is an antiseizure drug and is associated with antiepileptic activity. Clobazam is useful in treating chronic epileptic encephalopathy disorder, Lennox??Gastaut syndrome. It is employed in epilepsy and seizure prevention adjunctive therapy.