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GenScript

CLDN18.2, hFc, Human

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CLDN18.2, hFc, Human

Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. The Expression of Isoform A2 (CLDN18.2) is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level). CLDN18.2 is founded to be abundant in gastric tumors, Experimental antibody IMAB362 targets Claudin 18.2 to help treat gastric cancers.

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.


 
SpeciesHuman
Protein ConstructionCLDN18.2 (Full length) Accession # P56856-2 hFc
Purity≥ 75% as analyzed by SDS-PAGE
Endotoxin Level≤ 0.2 EU/μg of protein by gel clotting method
Biological ActivityImmobilized anti Claudin 18.2 antibody at 1 μg/ml (100 μl/Well). Dose response curve for CLDN18.2, hFc, Human with the EC50 of 17.60 ng/ml determined by ELISA.
Expression System293 Cells
FormulationSupplied as a solution in 20 mM PB, 500 mM NaCl, 10% glycerol, 0.025% DDM, 0.005% CHS, pH 7.0.
ConcentrationPlease refer to the COA for the specific lot.
Storage & StabilityUpon receiving, this product remains stable for up to 6 months at lower than -70°C. Avoid repeated freeze-thaw cycles.

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Product Detail
Thomas No.
CHM03U913
Mfr. No.
Z03709-1
Description
CLDN18.2, hFc, Human,1mg
list price/quantitytotal
$0.00
Thomas No.
CHM03U914
Mfr. No.
Z03709-100
Description
CLDN18.2, hFc, Human,100µg
list price/quantitytotal
$0.00
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