Synonyms: trans-4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-1H-indol-5-yl]amino]-4-pyrimidinyl]amino]-cyclohexanol
Molecular Formula: C27H32N6O
Molecular Weight: 456.58
Linear Structural Formula: C27H32N6O
Purity: >=95% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: CINK4 is a specific inhbitor of CDK4/cyclin D1 complexes (IC50 = 1.5 mM). CINK4 has greater than 50 fold selectivity over CDK1 or CDK2. CINK4 dose-dependently inhibits phosphorylation of retinoblastoma (Rb) and induces G0-G1 cell cycle arrest and apoptosis in cancer cell lines.