Synonyms: Ciclopirox; 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone; HOE 296b; 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone
Molecular Formula: C12H17NO2
Molecular Weight: 207.27
Linear Structural Formula: C12H17NO2
MDL Number: MFCD00599441
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Ciclopirox is an antifungal and cell-permeable iron-chelating agent. It has been found to inhibit multiple enzymes and signaling pathways including prolyl hydroxylase 2 (PHD2), eukaryotic translation initiation factor 5A (eIF5A), Wnt/beta-catenin, hypoxia-inducible factor-1alpha (HIF-1 alpha)/vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor 3 (VEGFR-3), mammalian target of rapamycin (mTOR), and cyclin dependent kinases (CDKs). Ciclopirox has been shown to have anti-viral and anticancer activity in addition to its antifungal activity. Ciclopirox has also been shown to counteract glucotoxicity in diabetic mice in a p21-dependent manner.