Choline chloride (ChCl) is a quaternary ammonium salt. The unusual solvent properties of eutectic mixtures of urea and choline chloride make it useful as a biodegradable ambient-temperature solvent for a number of applications; such as a reaction medium for the synthesis of coordination polymer: Zn(O3PCH2CO2)].NH4. Ethylene glycol/choline chloride and urea based eutectic solvents can be used for the electrodeposition of Zn, Sn and Zn/Sn alloys. Choline chloride.xZnCl2 participates as a catalyst during the reaction between benzaldehyde and neopentyl glycol.
Synonyms: (2-Hydroxyethyl)trimethylammonium chloride
Molecular Formula: C5H14ClNO
Molecular Weight: 139.62
Linear Structural Formula: (CH3)3N(Cl)CH2CH2OH
MDL Number: MFCD00011721
Melting Point: 302-305 C (dec.) (lit.)
Application: Choline chloride may be used as an analytical reference standard for the determination of choline in biological fluids and dairy products by high-throughput method based on normal-phase chromatography-tandem mass spectrometry and flow injection analysis and amperometric detection with a choline oxidase based biosensor, respectively.
Biochem Physiol Actions: The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .